Preferred Label : PI3K p110beta/delta Inhibitor KA2237;
NCIt synonyms : PI3 Kinase b/d Inhibitor KA2237;
NCIt definition : A dual selective inhibitor of the beta and delta isoforms of the 110 kDa catalytic
subunit of class I phosphoinositide-3 kinase (PI3K-beta/delta), with potential antineoplastic
activity. PI3K-beta/delta inhibitor KA2237 selectively inhibits the PI3K-beta and
-delta isoforms and prevents their activation, which inhibits PI3K-beta/delta-mediated
signal transduction pathways. This decreases proliferation and induces cell death
in susceptible tumor cells. Unlike other isoforms of PI3K, PI3K-beta and -delta are
overexpressed primarily in solid and hematological tumor cells and play crucial roles
in tumor cell survival, and immunoregulation. The targeted inhibition of these PI3Ks
allows this agent to potentially be more efficacious and less toxic than pan PI3K
inhibitors, which also affect normal, healthy cells.;
Molecule name : KA 2237; KA2237;
NCI Metathesaurus CUI : CL504848;
Origin ID : C126271;
UMLS CUI : C4287747;
Semantic type(s)
- concept_is_in_subset
- has_target
