NCIt related terms : 2-.beta.-D-Ribofuranosyl-4-thiazolecarboxamide; 4-Thiazolecarboxamide, 2-.beta.-D-ribofuranosyl- (9CI); 2-.beta.-D-Ribofuranosylthiazole-4-carboxamide;
NCIt definition : A synthetic nucleoside analogue with antineoplastic activity. Tiazofurin (TR) is anabolized
intracellularly to an analogue of NAD, tiazole-4-carboxamide adenine dinucleotide
(TAD), a potent inhibitor of IMP dehydrogenase (IMPDH); IMPDH is the rate-limiting
enzyme for de novo purine synthesis. Inhibition of IMPDH results in reduced levels
of guanylates, resulting in the inhibition tumor cell growth in vitro and in vivo.
(NCI04);
Alternative definition : NCI-GLOSS: An anticancer drug being studied to stop cell growth.;