" /> Tiazofurin - CISMeF





Preferred Label : Tiazofurin;

NCIt synonyms : 2-Beta-D-ribofuranosylthiazole-4-carboxamide; 4-Thiazolecarboxamide, 2-Beta-D-ribofuranosyl- (9CI); 2-Beta-D-ribofuranosyl-4-thiazolecarboxamide; TCAR; Tiazofurine;

NCIt related terms : 2-.beta.-D-Ribofuranosyl-4-thiazolecarboxamide; 4-Thiazolecarboxamide, 2-.beta.-D-ribofuranosyl- (9CI); 2-.beta.-D-Ribofuranosylthiazole-4-carboxamide;

NCIt definition : A synthetic nucleoside analogue with antineoplastic activity. Tiazofurin (TR) is anabolized intracellularly to an analogue of NAD, tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH); IMPDH is the rate-limiting enzyme for de novo purine synthesis. Inhibition of IMPDH results in reduced levels of guanylates, resulting in the inhibition tumor cell growth in vitro and in vivo. (NCI04);

Alternative definition : NCI-GLOSS: An anticancer drug being studied to stop cell growth.;

UNII : ULJ82834RE;

InChIKey : FVRDYQYEVDDKCR-DBRKOABJSA-N;

CAS number : 60084-10-8;

Drug name : Riboxamide;

Chemical formula : C9H12N2O5S;

NSC code : 286193;

Codes from synonyms : NSC0286193; CDR0000045242;

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28/05/2025


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