Preferred Label : Gallium Ga 68 Satoreotide Tetraxetan;
NCIt synonyms : 68Ga-DOTA-[Cpa-c(DCys-Aph(Hor)-DAph(Cbm)-Lys-Thr-Cys)-DTyr-NH2]; 68Ga-DOTA-Cpa-c[d-Cys-Aph(Hor)-d-Aph(Cbm)-Lys-Thr-Cys]-d-Tyr-NH2; Gallium Ga 68 DOTA-JR11; 68Ga-DOTA-JR11;
NCIt definition : A radioconjugate consisting of the somatostatin antagonistic peptide satoreotide that
is linked via the chelating agent tetraxetan (dodecanetetraacetic acid; DOTA), to
the beta-emitting radioisotope gallium Ga 68, with potential imaging activity during
positron emission topography/computed tomography (PET/CT). Upon administration, gallium
Ga 68 satoreotide tetraxetan binds to somatostatin receptors (SSTRs), with high affinity
for SSTR2, present on the cell membranes of many types of neuroendocrine tumor (NET)
cells. Upon binding and internalization, this radioconjugate can be used to quantify
tumor uptake of satoreotide using PET/CT. SSTRs have been shown to be present in large
numbers on NETs and their metastases, while most normal tissues express low levels
of SSTRs.;
CAS number : 1934243-18-1;
NCI Metathesaurus CUI : CL503799;
PubMed : 22851637;
Origin ID : C124930;
UMLS CUI : C4086988;
Semantic type(s)
- concept_is_in_subset
- has_target
