Ravulizumab - CISMeF

Preferred Label : Ravulizumab;

NCIt synonyms : Ravulizumab-cwvz;

NCIt definition : A longer-acting antibody directed against terminal complement protein C5, with potential anti-inflammatory activity. Upon administration, ravulizumab binds to terminal complement protein C5, thereby blocking C5 cleavage into pro-inflammatory components and preventing the complement-mediated destruction of red blood cells (RBCs) as seen in paroxysmal nocturnal hemoglobinuria (PNH). Compared to other anti-C5 antibodies, ALXN1210 is longer-acting and allows for monthly dosing. C5, a complement pathway protein, is expressed at high levels by the liver.;

UNII : C3VX249T6L;

CAS number : 1803171-55-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1803171-55-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Ultomiris;

Molecule name : ALXN 1210; ALXN1210;

NCI Metathesaurus CUI : CL502889;

Codes from synonyms : 94609;

Details

Origin ID

C124657;

UMLS CUI

C4550350;

Automatic exact mappings (from CISMeF team)
- Ravulizumab [ICD-11 Extension code]
Currated CISMeF NLP mapping
- Ravulizumab [LOINC component]
- Ravulizumab (substance) [SNOMED CT concept]
- ravulizumab [MeSH Supplementary Concept]
- ravulizumab [MeSH concept]
See also inter- (CISMeF)
- Product containing ravulizumab (medicinal product) [SNOMED CT concept]
- Ultomiris [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing ravulizumab (medicinal product) [SNOMED CT concept]
- Ravulizumab [LOINC component]
- Ravulizumab (substance) [SNOMED CT concept]
- ravulizumab [MeSH Supplementary Concept]
- ravulizumab [ATC Code]
Validated automatic mappings to BTNT
- ravulizumab [ATC Code]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_target
- Complement C5 [NCIt concept]

Keyword's position in hierarchy(ies) :

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