Preferred Label : Temozolomide;
NCIt synonyms : 3,4-dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide; 8-carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one; Temomedac; TMZ;
NCIt related terms : Methazolastone; Temodar; Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-;
NCIt definition : A triazene analog of dacarbazine with antineoplastic activity. As a cytotoxic alkylating
agent, temozolomide is converted at physiologic pH to the short-lived active compound,
monomethyl triazeno imidazole carboxamide (MTIC). The cytotoxicity of MTIC is due
primarily to methylation of DNA at the O6 and N7 positions of guanine, resulting in
inhibition of DNA replication. Unlike dacarbazine, which is metabolized to MITC only
in the liver, temozolomide is metabolized to MITC at all sites. Temozolomide is administered
orally and penetrates well into the central nervous system. (NCI04);
Alternative definition : NCI-GLOSS: A drug that is used to treat certain types of brain tumors in adults and
is being studied in the treatment of other types of cancer. It belongs to the family
of drugs called alkylating agents.;
UNII : YF1K15M17Y;
InChIKey : BPEGJWRSRHCHSN-UHFFFAOYSA-N;
CAS number : 85622-93-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 85622-93-1
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G-SRS /a ;
Drug name : Methazolastone; Temodar; Temodal; Temcad; Gliotem; Temizole;
Molecule name : SCH 52365; RP-46161; CCRG-81045; M & B 39831;
Chemical formula : C6H6N6O2;
NSC code : 362856;
Codes from synonyms : NSC0362856; 50556; CDR0000507640; CDR0000045387; 484;
Origin ID : C1244;
UMLS CUI : C0076080;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
