Preferred Label : Asymmetric Dimethylarginine;
NCIt synonyms : ADMA; Guanidino-N(1),N(1)-Dimethylarginine; N(G),N(G)-Dimethylarginine; Guanidino-N,N-Dimethylarginine; N(G1),N(G1)-Dimethylarginine;
NCIt related terms : N,N-DIMETHYLARGININE;
NCIt definition : A dimethylated derivative of L-arginine where the two methyl groups are attached to
arginine in an asymmetrical configuration. Asymmetric dimethylarginine (ADMA) is a
competitive inhibitor of nitric oxide synthase (NOS) that is formed when S-adenosylmethionine
protein N-methyltransferases transfer two methyl groups from S-adenosylmethionine
to one of the two guanidine nitrogen groups of an arginine residue in a protein. ADMA
is released when the protein is degraded and is a substrate for dimethylarginine dimethylaminohydrolase
(DDAH). Free ADMA in plasma competes with the L-arginine for binding to the heme in
NOS and inhibits nitric oxide (NO) synthesis. Decreased synthesis of NO inhibits vasodilation
and leads to endothelial dysfunction. Elevated plasma levels of ADMA are seen in certain
types of cancer, cardiovascular disease, hypertension, hyperlipidemia, type 2 diabetes
mellitus, and increased oxidative stress.;
UNII : 63CV1GEK3Y;
CAS number : 30315-93-6;
ChEBI ID : CHEBI:17929;
Origin ID : C124264;
UMLS CUI : C0067385;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
