Preferred Label : Fluorine F 18 FP-R01-MG-F2;
NCIt synonyms : [18F] FP-R01-MG-F2;
NCIt definition : A radiotracer composed of the integrin alphaVbeta6 (aVb6) ligand and cystine knot
peptide R01 variant R01-MG-F2 radiolabeled with [18F]-fluoropropionate (F 18 FP),
with potential integrin aVb6 imaging activity using positron emission tomography (PET).
Upon administration, the R01-MG-F2 moiety of fluorine F 18 FP-R01-MG-F2 selectively
binds to integrin aVb6-positive cancer cells. During PET, aVb6-expressing tumor cells
can be visualized. Integrin aVb6, a cell adhesion and signaling receptor, is upregulated
in certain cancer cell types and has been associated with increased proliferation
of tumor cells. The cystine knot peptide shows high stability and allows for rapid
and high uptake into aVb6-expressing tumor cells.;
NCI Metathesaurus CUI : CL502610;
Origin ID : C124230;
UMLS CUI : C4086318;
Semantic type(s)
- concept_is_in_subset
- has_target
