Preferred Label : Tamrintamab Pamozirine;
NCIt synonyms : ADC SC-003; Immunoglobulin G1(226-serine), Anti-(Human Dipeptidase 3)(Human-mus musculus Monoclonal
sc34.28SS1 Gamma1-chain), Compd. with Human-mus musculus Monoclonal sc34.28SS1 Kappa-chain,
Dimer, Bis(thioether) with N-(6-(3-mercapto-2, 5-dioxo-1-pyrrolidinyl)-1;
NCIt definition : An antibody-drug conjugate (ADC) composed of a humanized immunoglobulin G1 (IgG1)
monoclonal antibody against dipeptidase 3 (DPEP3) conjugated, via a plasma-stable
valine-alanine dipeptide linker, to a cytotoxic pyrrolobenzodiazepine (PBD) dimer,
with potential antineoplastic activity. Upon administration, the monoclonal antibody
moiety of tamrintamab pamozirine targets DPEP3 expressed on tumor cells. Upon binding
and internalization, the cytotoxic, DNA cross-linking PBD moiety is released. This
inhibits DNA replication, leads to G2/M cell cycle arrest, induces cell death, and
inhibits the proliferation of DPEP3-expressing tumor cells. DPEP3, a membrane-bound
glycoprotein, is overexpressed in some ovarian cancers.;
UNII : GM0RU5SU0E;
CAS number : 2148334-68-1;
Molecule name : SC 003; SC-003;
NCI Metathesaurus CUI : CL502529;
Origin ID : C124133;
UMLS CUI : C5239417;
Semantic type(s)
- concept_is_in_subset
- has_target
