Preferred Label : Oleclumab;
NCIt synonyms : Anti-CD73 Monoclonal Antibody MEDI9447;
NCIt definition : A monoclonal antibody against the ectoenzyme CD73 (cluster of differentiation 73),
also known as 5'-nucleotidase (5'-NT; ecto-5'-nucleotidase) with potential antineoplastic
activity. Upon administration, oleclumab targets and binds to CD73, leading to clustering
of and internalization of CD73. This prevents CD73-mediated conversion of adenosine
monophosphate (AMP) to adenosine and decreases the amount of free adenosine. This
prevents adenosine-mediated lymphocyte suppression and increases the activity of CD8-positive
effector cells. This also activates macrophages, and reduces both myeloid-derived
suppressor cells (MDSCs) and regulatory T-lymphocytes. By abrogating the inhibitory
effect on the immune system and enhancing the cytotoxic T-cell-mediated immune response
against cancer cells, tumor cell growth decreases. In addition, clustering and internalization
of CD73 decreases the migration of cancer cells and prevents metastasis. CD73, a plasma
membrane protein upregulated on a number of cancer cell types, catalyzes the conversion
of extracellular nucleotides, such as AMP, to membrane-permeable nucleosides, such
as adenosine; it plays a key role in adenosine-mediated immunosuppression within the
tumor microenvironment.;
UNII : 5CRY01URYQ;
CAS number : 1803176-05-7;
Molecule name : MEDI9447;
NCI Metathesaurus CUI : CL498278;
Origin ID : C123914;
UMLS CUI : C4763384;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
