Preferred Label : Anti-DLL3 Antibody-drug Conjugate SC-002;
NCIt synonyms : Anti-DLL3 ADC SC-002;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
the tumor-associated antigen (TAA) delta-like protein 3 (DLL3), site-specifically
conjugated to the cytotoxic pyrrolobenzodiazepine (PBD) dimer SC-DR002 via a plasma-stable
valine-alanine dipeptide linker, with potential antineoplastic activity. Upon intravenous
administration, the monoclonal antibody moiety of anti-DLL3 ADC SC-002 targets and
binds to DLL3 expressed on tumor cells. Upon binding and internalization, the dipeptide
linker is cleaved upon cathepsin-mediated proteolysis and SC-DR002 is released. Then
the imine groups of the PBD moiety bind to the N2 positions of guanines on opposite
strands of DNA. This induces DNA strand breaks, inhibits DNA replication, leads to
G2/M cell cycle arrest, induces cell death, and inhibits the proliferation of DLL3-overexpressing
tumor cells. DLL3, a membrane protein that binds to Notch receptors and regulates
Notch-mediated signaling and gene transcription, is overexpressed by certain cancers
but is rarely expressed by normal, healthy cells.;
Molecule name : SC-002; SC 002;
Origin ID : C123284;
UMLS CUI : C0967624;
Currated CISMeF NLP mapping
- SC002 [MeSH Supplementary Concept]
- Semantic type(s)
- UMLS correspondences (same concept)
- SC002 [MeSH Supplementary Concept]
- concept_is_in_subset
- has_target
