Preferred Label : Mps1 Inhibitor BAY 1217389;
NCIt synonyms : TTK Inhibitor BAY 1217389;
NCIt definition : An orally bioavailable, selective inhibitor of the serine/threonine kinase monopolar
spindle 1 (Mps1, TTK), with potential antineoplastic activity. Upon administration,
the Mps1 inhibitor BAY 1217389 selectively binds to and inhibits the activity of Mps1.
This inactivates the spindle assembly checkpoint (SAC), accelerates mitosis, causes
chromosomal misalignment and missegregation, and mitotic checkpoint complex destabilization.
This induces cell death in Mps1-overexpressing cancer cells. Mps1, a kinase expressed
in proliferating normal tissues and aberrantly overexpressed in a wide range of human
tumors, is activated during mitosis and is essential for proper SAC functioning and
chromosome alignment.;
Molecule name : BAY 1217389;
Origin ID : C122707;
UMLS CUI : C4053670;
Semantic type(s)
- concept_is_in_subset
- has_target
