Acute Myeloid Leukemia with t(7;12)(q36;p13); HLXB9-ETV6

Preferred Label : Acute Myeloid Leukemia with t(7;12)(q36;p13); HLXB9-ETV6;

NCIt synonyms : Acute Myeloid Leukemia with t(7;12)(q36;p13); MNX1-ETV6; Acute Myeloid Leukemia with t(7;12)(q36;p13); MNX1::ETV6;

NCIt related terms : AML with t(7;12)(q36;p13); HLXB9-ETV6; AML with t(7;12)(q36;p13); MNX1-ETV6;

NCIt definition : An acute myeloid leukemia in infancy characterized by t(7;12)(q36;p13) and fusion of the homeobox gene HLXB9 (MNX1) with the ETV6 gene.;

Alternative definition : NICHD: An acute myeloid leukemia in infancy characterized by t(7;12)(q36;p13) and fusion of the homeobox gene HLXB9 with the ETV6 gene. This is seen in 3% of children with AML.;

Neoplastic status : Malignant;

Details

Origin ID

C122690;

UMLS CUI

C4055493;

Disease excludes abnormal cell
- Neoplastic Lymphoblast [NCIt concept]
Disease excludes normal cell origin
- Lymphocyte [NCIt concept]
Disease may have findings
- Hypercellular Bone Marrow [NCIt concept]
Has associated anatomic sites
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
Has cytogenetic abnormalities
- t(7;12)(q36;p13) [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
concept_is_in_subset
- NCIt Neoplasm Core Terminology [NCIt concept]
- NICHD Terminology [NCIt concept]
- Pediatric Hematology-Oncology Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Chronic Clinical Course [NCIt concept]
- Solid Growth Pattern [NCIt concept]
disease_has_abnormal_cell
- Leukemic Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Myeloblast [NCIt concept]
- Neoplastic Myeloid Cell [NCIt concept]
disease_has_finding
- Childhood Lesion [NCIt concept]
- Infantile Lesion [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
disease_has_normal_cell_origin
- Bone Marrow Stem Cell [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic Tissue [NCIt concept]
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
disease_mapped_to_gene
- MNX1/ETV6 Fusion Gene [NCIt concept]
pathogenesis_of_disease_involves_gene
- MNX1/ETV6 Fusion Gene [NCIt concept]

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