Preferred Label : Miglustat;
NCIt synonyms : 1,5-(butylimino)-1,5-dideoxy-D-glucitol; N-Butyl Deoxynojirimycin; N-Butylmoranoline; 3,4,5-Piperidinetriol, 1-butyl-2-(hydroxymethyl)-,(2R-(2alpha,3beta,4alpha,5beta))-;
NCIt definition : A synthetic, N-alkylated imino analogue of D-glucose. Miglustat competitively and
reversibly binds to and inhibits the activity of UDP-glucose ceramide glucosyltransferase,
which catalyzes the initial step in the synthesis of glycosphingolipids (GSL). This
leads to a decrease in the production of glycosphingolipid, which has important roles
in various cellular processes. Miglustat can be used in substrate reduction therapy
in diseases in which the enzyme glucocerebrosidase, that is responsible for the breakdown
of GSL, is deficient.;
UNII : ADN3S497AZ;
InChIKey : UQRORFVVSGFNRO-UTINFBMNSA-N;
CAS number : 72599-27-0;
Drug name : Zavesca;
Molecule name : SC-48334; SC 48334;
Chemical formula : C10H21NO4;
ChEBI ID : CHEBI:50381;
Codes from synonyms : 32222;
Origin ID : C1222;
UMLS CUI : C1321596;
Semantic type(s)
UMLS correspondences (same concept)
Validated automatic mappings to BTNT
concept_is_in_subset