Preferred Label : Gallium Ga 68-HA-DOTA-TATE;
NCIt synonyms : 68Ga-DOTA-iodoTyr3-octreotate; [68Ga]DOTA-3-iodo-Tyr3-octreotate; 68Ga-HA-DOTATATE; 68Ga-DOTA-3-iodo-Tyr3-octreotate; [68Ga]high-affinity DOTATATE;
NCIt definition : A radioconjugate consisting of consisting of the high affinity somatostatin analogue
iodo-tyrosine-3-octreotate (HA-TATE), labeled with the positron emission tomography
(PET) tracer gallium Ga 68 via the macrocyclic chelating agent 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra-acetic
acid (DOTA), which may be used as a human somatostatin receptor (SSTR) imaging agent
in conjunction with PET to image neuroendocrine tumors (NETs). Gallium Ga 68-HA-DOTATATE
binds to SSTRs, with high affinity for SSTR2, present on the cell membranes of many
types of NETs. This allows for visualization of SSTR-positive cells upon imaging.
SSTRs have been shown to be present in large numbers on NETs and their metastases,
while most other normal tissues express low levels of SSTRs. HA-TATE is an octreotide
derivative in which phenylalanine at position 3 is substituted with iodo-tyrosine
and threoninol at position 8 is replaced by threonine. The iodo addition in Gallium
Ga 68-HA-DOTA-TATE may allow for higher affinity for the SSTRs when compared to gallium
Ga 68-DOTA-TATE.;
Origin ID : C122036;
UMLS CUI : C4042682;
CISMeF manual mappings
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
