" /> Tislelizumab - CISMeF





Preferred Label : Tislelizumab;

NCIt synonyms : Tirelizumab;

NCIt definition : A monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed cell death 1 (PD-1), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, tislelizumab binds to PD-1 and inhibits the binding of PD-1 to the PD-1 ligands programmed cell death-1 ligand 1 (PD-L1), and PD-1 ligand 2 (PD-L2). This prevents the activation of PD-1 and its downstream signaling pathways. This may restore immune function through the activation of both T-cells and T-cell-mediated immune responses against tumor cells. PD-1, a transmembrane protein in the immunoglobulin (Ig) superfamily expressed on activated T-cells, negatively regulates T-cell activation and effector function when activated by its ligands; it plays an important role in tumor evasion from host immunity.;

UNII : 0KVO411B3N;

CAS number : 1858168-59-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1858168-59-8 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : BGB-A317;

Codes from synonyms : 64463;

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Keyword's position in hierarchy(ies) : arborescence

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15/05/2024


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