" /> Gallium Ga 68 Citrate - CISMeF





Preferred Label : Gallium Ga 68 Citrate;

NCIt synonyms : Gallium-68 Citrate; (68)Ga-citrate; 68Ga-Citrate;

NCIt related terms : GALLIUM CITRATE GA-68;

NCIt definition : A radiopharmaceutical citrate salt form of the positron-emitting radioisotope gallium Ga 68, with potential imaging activity upon positron emission tomography (PET). Upon administration of Gallium Ga 68 citrate, the gallium Ga 3 ion dissociates from the weak citrate chelator. As Ga3 is very similar to iron (Fe3 ) in chemical properties, this ion acts as an iron analogue. Ga3 binds to the iron-binding protein transferrin, distributes in blood, and enters and accumulates in the extracellular fluid space of inflamed or tumor-bearing tissue. In turn, the Ga3 -transferrin complex binds to transferrin receptors and is taken up by tumor cells. Tumor cells can then be imaged upon PET. Compared to healthy cells, tumor cells have increased iron metabolism and transferrin receptor expression. Increased Ga3 uptake is seen in inflamed and infected tissues as well.;

UNII : RD9L8XE13L;

CAS number : 56578-07-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 56578-07-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

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17/06/2024


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