Preferred Label : Cemiplimab;
NCIt synonyms : Immunoglobulin G4, Anti-(Human Programmed Cell Death Protein 1) (Human Monoclonal
REGN2810 Heavy Chain), Disulfide with Human Monoclonal REGN2810 kappa-chain, Dimer; Cemiplimab RWLC; Cemiplimab-rwlc;
NCIt definition : A human monoclonal antibody directed against the negative immunoregulatory human cell
surface receptor programmed cell death 1 (PD-1, PCD-1) protein, with potential immune
checkpoint inhibitory and antineoplastic activity. Upon administration, cemiplimab
binds to PD-1, inhibits its binding to the PD-1 ligand programmed cell death-1 ligand
1 (PD-L1), and prevents the activation of its downstream signaling pathways. This
may restore immune function through the activation of cytotoxic T-cells. PD-1, a transmembrane
protein in the immunoglobulin superfamily expressed on activated T-cells, negatively
regulates T-cell activation and effector function when activated by its ligand; it
plays an important role in tumor evasion from host immunity.;
UNII : 6QVL057INT;
CAS number : 1801342-60-8;
Drug name : Libtayo;
Molecule name : REGN-2810; REGN 2810;
Codes from synonyms : 95;
Origin ID : C121540;
UMLS CUI : C4724806;
Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
- is_component_of_chemotherapy_regimen
