Preferred Label : Ibuprofen Injection;
NCIt definition : A formulation for intravenous injection containing ibuprofen, a propionic acid derivate
and nonsteroidal anti-inflammatory drug (NSAID), with anti-inflammatory, analgesic,
and antipyretic activities. Upon intravenous injection, ibuprofen inhibits the activity
of the enzymes cyclooxygenase I (COX-1) and II (COX-2), resulting in a decreased formation
of precursors of prostaglandins and thromboxanes. Inhibition of COX-2 specifically
blocks the conversion of arachidonic acid (AA) to prostaglandins, which mediate inflammation,
fever and pain.;
Drug name : Caldolor;
Origin ID : C120315;
UMLS CUI : C3892043;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
