Preferred Label : Src/tubulin Inhibitor KX2-361;
NCIt synonyms : Src/tubulin Inhibitor KX02;
NCIt related terms : KX2-361;
NCIt definition : A lipophilic, orally available inhibitor of both Src kinase activity and tubulin polymerization,
with potential antineoplastic activity. Upon oral administration,Src/tubulin Inhibitor
KX2-361 binds to and inhibits the activity of Src kinase. This inhibits both downstream
signaling and the proliferation of Src kinase-expressing tumor cells. KX02 also binds
to tubulin heterodimers and inhibits microtubule polymerization, thereby disrupting
microtubule formation, mitosis, and further proliferation. Src, a non-receptor tyrosine
kinase, is overexpressed in a variety of tumor cell types and plays a key role in
tumor cell proliferation, angiogenesis, migration, and metastasis.;
UNII : RVW387BA9U;
CAS number : 897016-26-1;
Molecule name : KX02; KX2-361;
Origin ID : C120101;
UMLS CUI : C5667148;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
