Preferred Label : Cholate;
NCIt synonyms : 3alpha,7alpha,12alpha-Trihydroxy-5beta-Cholanate; 3alpha,7alpha,12alpha-Trihydroxy-5beta-Cholan-24-Oate;
NCIt definition : An ester or salt of the bile acid cholic acid that is synthesized in the liver from
cholesterol, with surfactant and signaling activities in the liver and intestine.
In the intestine, cholate acts as a surfactant that promotes the absorption of dietary
lipids and fat-soluble vitamins. In the liver, cholate's surfactant activity facilitates
biliary excretion of xenobiotics and metal cations. Cholate binds to nuclear receptors,
including farnesoid X receptor (FXR), pregnane X receptor (PXR), and the vitamin D
receptor (VDR), which directly modulate gene transcription. Cholate may also be used
as a biomarker for hepatotoxicity.;
ChEBI ID : CHEBI:29747;
Origin ID : C120004;
UMLS CUI : C0109497;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
- concept_is_in_subset
