KNSTRN wt Allele

Preferred Label : KNSTRN wt Allele;

NCIt synonyms : FLJ14502; HSD11; TRAF4AF1; C15orf23; Kinetochore-Localized Astrin/SPAG5 Binding Protein wt Allele; SKAP; Small Kinetochore-Associated Protein, Kinetochore-Localized Astrin-Binding Protein, TRAF4 Associated Factor 1 Gene; Chromosome 15 Open Reading Frame 23 Gene;

NCIt definition : Human KNSTRN wild-type allele is located in the vicinity of 15q15.1 and is approximately 12 kb in length. This allele, which encodes small kinetochore-associated protein, is involved in the metaphase/anaphase transition of the mitotic cell cycle.;

NCIt note : Genetic variation in the KNSTRN gene may be associated with cutaneous squamous cell carcinoma. (Nature Genetics. 2014; 46: 1060-1062. doi:10.1038/ng.3091);

GenBank Accession Number : AK027408;

PubMed : 25194279;

Details

Origin ID

C119653;

UMLS CUI

C3890201;

Automatic exact mappings (from CISMeF team)
- Kinetochore-localized astrin/spag5-binding protein [OMIM gene]
- hydroxysteroid 11-beta dehydrogenase 1 [ORDO Gene]
- kinetochore localized astrin (SPAG5) binding protein [ORDO Gene]
- soaps [MeSH Descriptor]
OMIM relation
- Kinetochore-localized astrin/spag5-binding protein [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_plays_role_in_process
- Cell Cycle Process [NCIt concept]
- Cell Cycle Progression [NCIt concept]
- Cell Cycle Regulation Process [NCIt concept]
- Chromosome Segregation [NCIt concept]

Keyword's position in hierarchy(ies) :

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