Beta-Klotho - CISMeF

Preferred Label : Beta-Klotho;

NCIt synonyms : BetaKlotho; BKL; Klotho Beta-Like Protein; KLB;

NCIt definition : Beta-klotho (1044 aa, 120 kDa) is encoded by the human KLB gene. This protein is involved in the regulation of growth factor-dependent signaling.;

NCIt note : Beta-klotho shares some homology with glycosidases but does not appear to be active in vivo. (UniProt);

Details

Origin ID

C119645;

UMLS CUI

C2714298;

Automatic exact mappings (from CISMeF team)
- Klotho, beta [OMIM gene]
OMIM relation
- Klotho, beta [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- KLB protein, human [MeSH Supplementary Concept]
- KLB protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- KLB Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- FGF Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Growth Factor Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Transcriptional Repression [NCIt concept]

Keyword's position in hierarchy(ies) :

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