LMP1/BARF1/EBNA1-specific Cytotoxic T-lymphocytes

Preferred Label : LMP1/BARF1/EBNA1-specific Cytotoxic T-lymphocytes;

NCIt synonyms : LMP1/BARF1/EBNA-1 Minimum Anticipated Biological Effect Level Cytotoxic T-lymphocytes; LMP1/BARF1/EBNA-1 MABEL CTLs; LMP1/BARF1/ EBNA1-specific CTLs;

NCIt definition : A preparation of allogeneic cytotoxic T-lymphocytes (CTL) made specifically reactive to three Epstein-Barr virus (EBV) proteins, latent membrane protein (LMP) 1, BamH1-A rightward frame-1 (BARF1) and EBV nuclear antigen 1 (EBNA1), with potential antineoplastic activity. Administration of LMP1/BARF1/ EBNA1-specific CTLs to patients with LMP1/BARF1/EBNA1-positive tumors may result in a specific CTL response against the tumor cells expressing these antigens, which can result in both cell lysis and the inhibition of tumor cell proliferation. LMP1, BARF1 and EBNA1 are expressed in various, EBV-associated malignancies, including nasopharyngeal cancer and EBV-positive Hodgkin lymphoma.;

Details

Origin ID

C118956;

UMLS CUI

C3896577;

Semantic type(s)
- Cell [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Epstein-Barr Nuclear Antigen 1 [NCIt concept]
- Latent Membrane Protein 1 [NCIt concept]

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