Preferred Label : Sulanemadlin;
NCIt synonyms : MDM2/MDMX Inhibitor ALRN-6924;
NCIt definition : An orally available peptide inhibitor of both murine double minute 2 (MDM2) and murine
double minute X (MDMX), with potential antineoplastic activity. Upon oral administration,
sulanemadlin binds to both MDM2 and MDMX and interferes with their interaction with
the transcriptional activation domain of the tumor suppressor protein p53. By preventing
MDM2-p53 and MDMX-p53 interactions, p53 activity is restored, which leads to p53-mediated
induction of tumor cell apoptosis. MDM2 and MDMX, negative regulators of p53 function,
are often overexpressed in cancer cells.;
UNII : 6BGF28R54M;
CAS number : 1451199-98-6;
Molecule name : ALRN-6924;
Origin ID : C118669;
UMLS CUI : C5446796;
Semantic type(s)
- concept_is_in_subset
- has_target
