Preferred Label : Activin Type 2B Receptor Fc Fusion Protein STM 434;
NCIt synonyms : Activin Inhibitor STM 434;
NCIt related terms : STM-434;
NCIt definition : A soluble fusion protein containing the extracellular domain of the activin receptor
type 2B (ACVR2B or ActRIIB) fused to a human Fc domain, with potential antineoplastic
activity. Upon intravenous administration, STM 434 selectively binds to the growth
factor activin A, thereby preventing its binding to and the activation of endogenous
ActRIIB. This prevents activin A/ActRIIB-mediated signaling and inhibits the proliferation
of activin A-overexpressing tumor cells. Activin A, a member of the transforming growth
factor beta (TGF-beta) superfamily, is overexpressed in a variety of cancers and plays
a key role in promoting cancer cell proliferation, migration, and survival.;
UNII : 7G4D2B5AC8;
CAS number : 2055761-25-4;
Molecule name : STM 434;
Origin ID : C118625;
UMLS CUI : C3896763;
Semantic type(s)
- concept_is_in_subset
- has_target
