Preferred Label : Anti-TROP-2 Antibody-drug Conjugate PF-06664178;
NCIt synonyms : Anti-TROP-2/Aur0101 ADC PF-06664178; Anti-TROP-2 ADC PF-06664178;
NCIt definition : An antibody-drug conjugate (ADC) composed of PF-06478924 (RN926), a humanized immunoglobulin
G1 (IgG1) monoclonal antibody targeting the tumor-associated antigen (TAA) trophoblast
cell surface protein 2 (trophoblast antigen 2; calcium signal transducer 2; TROP2;
TROP-2; TACSTD2; GA733-1; M1S1), site-specifically conjugated via a valine-citrulline
cleavable linker with the auristatin-based cytotoxic agent Aur0101 (PF-06380101),
with potential antineoplastic activity. Upon administration of anti-TROP-2 ADC PF-06664178,
the anti-TROP-2 monoclonal antibody moiety PF-06478924 targets and binds to TROP-2
expressed on tumor cells. Upon binding, internalization and linker cleavage, Aur0101
binds to tubulin and inhibits its polymerization, resulting in G2/M phase arrest and
apoptosis of TROP-2-expressing tumor cells. TROP-2 is a transmembrane protein overexpressed
in various tumors. Its expression is associated with enhanced tumor aggressiveness,
metastasis, drug resistance and increased tumor cell survival.;
Molecule name : PF-06664178; RN-927C; RN 927C; PF 06664178;
NCI Metathesaurus CUI : CL474086;
Origin ID : C118570;
UMLS CUI : C3896786;
Semantic type(s)
- concept_is_in_subset
- has_target
