G1/S-Specific Cyclin-D1b

Preferred Label : G1/S-Specific Cyclin-D1b;

NCIt synonyms : Cyclin-D1b; Cyclin D1b; CCND1b; G1/S-Specific Cyclin D1b;

NCIt definition : G1/S-specific cyclin-D1b is encoded by the human CCND1 gene. This protein may play a role in the promotion of tumor cell invasiveness and anchorage-independent growth.;

NCIt note : G1/S-specific cyclin-D1b is an isoform of G1/S-specific cyclin-D1 that is missing the amino acids encoded by exon 5 because of a genetic variant that causes splicing failure at the exon-4/intron-4 boundary of the CCND1 gene. The deleted region includes the regulatory threonine at position 286, which in the wild-type protein can be phosphorylated by mitogen activated protein kinases to induce the ubiqutination and degradation of the protein.;

Details

Origin ID

C118477;

UMLS CUI

C3893229;

OMIM relation
- Cyclin d1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CCND1 Gene [NCIt concept]
- Cell Cycle Gene [NCIt concept]
- Cyclin Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_abnormality
- Protein Truncation Abnormality [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Regulatory Protein [NCIt concept]
gene_product_has_chemical_classification
- Cyclin D [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- Invasion [NCIt concept]
- Stimulation of Cancer Cell Growth [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients