Cannabidiol - CISMeF

Preferred Label : Cannabidiol;

NCIt synonyms : 1,3-Benzenediol, 2-(3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl)-5-pentyl-, (1R-trans)-; CBD Oil;

NCIt related terms : CBD;

NCIt definition : A phytocannabinoid derived from Cannabis species, which is devoid of psychoactive activity, with analgesic, anti-inflammatory, antineoplastic and chemopreventive activities. Upon administration, cannabidiol (CBD) exerts its anti-proliferative, anti-angiogenic and pro-apoptotic activity through various mechanisms, which likely do not involve signaling by cannabinoid receptor 1 (CB1), CB2, or vanilloid receptor 1. CBD stimulates endoplasmic reticulum (ER) stress and inhibits AKT/mTOR signaling, thereby activating autophagy and promoting apoptosis. In addition, CBD enhances the generation of reactive oxygen species (ROS), which further enhances apoptosis. This agent also upregulates the expression of intercellular adhesion molecule 1 (ICAM-1) and tissue inhibitor of matrix metalloproteinases-1 (TIMP1) and decreases the expression of inhibitor of DNA binding 1 (ID-1). This inhibits cancer cell invasiveness and metastasis. CBD may also activate the transient receptor potential vanilloid type 2 (TRPV2), which may increase the uptake of various cytotoxic agents in cancer cells. The analgesic effect of CBD is mediated through the binding of this agent to and activation of CB1.;

UNII : 19GBJ60SN5;

InChIKey : QHMBSVQNZZTUGM-ZWKOTPCHSA-N;

CAS number : 13956-29-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 13956-29-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Epidiolex;

Molecule name : GWP42003-P;

Details

Origin ID

C118452;

UMLS CUI

C0006863;

Currated CISMeF NLP mapping
- Cannabidiol [LOINC component]
- Cannabidiol [ICD-11 Extension code]
- Cannabidiol (substance) [SNOMED CT concept]
- cannabidiol [MeSH Descriptor]
- cannabidiol [SNOMED Notion]
- cannabidiol [MeSH concept]
False automatic mappings
- Colorblindness, partial, deutan series [OMIM Phenotype]
- Corticobasal degeneration [ICD-11 More detail]
- opsin 1, medium wave sensitive [ORDO Gene]
See also inter- (CISMeF)
- Product containing cannabidiol (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Cannabidiol [LOINC component]
- Cannabidiol (substance) [SNOMED CT concept]
- Product containing cannabidiol (medicinal product) [SNOMED CT concept]
- cannabidiol [SNOMED Notion]
- cannabidiol [MeSH Descriptor]
- cannabidiol [MeSH concept]
- cannabidiol [ATC Code]
Validated automatic mappings to BTNT
- cannabidiol [ATC Code]
concept_is_in_subset
- CRF4 Treatment Complementary Table [NCIt concept]
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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