NCIt definition : A monoclonal antibody against the tumor associated antigen (TAA) mucin-1 (MUC1), with
potential antineoplastic activity. Upon administration, anti-MUC1 monoclonal antibody
BTH1704 targets and binds to MUC1 expressed on the surface of tumor cells, which can
potentially activate the immune system to induce an antibody-dependent cellular cytotoxicity
(ADCC) against MUC1-expressing tumor cells. MUC1, a glycoprotein overexpressed on
the surface of a variety of cancer cells, plays a key role in tumor cell survival
and proliferation.;