Piroxantrone - CISMeF

Preferred Label : Piroxantrone;

NCIt synonyms : Piroxantrone HCl; Oxantrazole; Anthra(1,9-cd)pyrazol-6(2H)-one, 5-((3-aminopropyl)amino)-7,10-dihydroxy-2-(2-((2-hydroxyethyl)amino)ethyl);

NCIt related terms : Oxanthrazole;

NCIt definition : An anthrapyrazole antineoplastic antibiotic. Piroxantrone intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Although less cardiotoxic than doxorubicin, this agent exhibits a narrow spectrum of antineoplastic activity. (NCI04);

UNII : YL4TY9WH22;

InChIKey : QEWPVAOWLNMLRI-UHFFFAOYSA-N;

CAS number : 91441-23-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 91441-23-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : PD-111815; CI-942;

Chemical formula : C21H25N5O4;

NSC code : 349174;

Codes from synonyms : NSC0349174;

Details

Origin ID

C1182;

UMLS CUI

C0069736;

Automatic exact mappings (from CISMeF team)
- anthrapyrazole [MeSH Supplementary Concept]
- anthrapyrazole [MeSH concept]
Currated CISMeF NLP mapping
- piroxantrone [MeSH concept]
- piroxantrone [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- piroxantrone [MeSH concept]
- piroxantrone [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Piroxantrone Hydrochloride [NCIt concept]
is_component_of_chemotherapy_regimen
- Filgrastim/Piroxantrone [NCIt concept]
- Piroxantrone/Sargramostim [NCIt concept]
is_free_acid_or_base_form_of
- Piroxantrone Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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