Preferred Label : Nanoparticle Albumin-bound Thiocolchicine Dimer nab-5404;
NCIt synonyms : nab-Thiocolchicine Dimer;
NCIt related terms : IDN-5404;
NCIt definition : A nanoparticle albumin-bound formulation of a thiocolchicine dimer, an inhibitor of
both microtubule and topoisomerase I (TOP1), with antineoplastic and vascular disrupting
activities. Upon administration of nanoparticle albumin-bound thiocolchicine dimer
nab-5404, this agent binds to tubulin and inhibits its polymerization, which blocks
mitotic spindle formation and leads to cell cycle arrest and tumor endothelial cell
apoptosis. This disrupts the tumor vasculature and leads to tumor necrosis. In addition,
nab-5404 binds to topoisomerase I (TOPI) and inhibits its activity. This results in
the inhibition of the repair of single-strand DNA breaks, DNA replication, and tumor
cell growth in susceptible tumor cell populations. The nanoparticle albumin-based
formulation permits the albumin-mediated endocytosis of the thiocolchicine dimer by
tumor cells and endothelial cells.;
UNII : 5C3JG9RQU3;
CAS number : 361169-05-3;
Molecule name : IDN 5404; ABI-011; NTB-011; nab-5404;
NCI Metathesaurus CUI : CL421664;
Origin ID : C116890;
UMLS CUI : C3896838;
Semantic type(s)
- concept_is_in_subset
- has_target
