Preferred Label : Paxalisib;
NCIt synonyms : PI3K Inhibitor GDC-0084;
NCIt definition : A phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity.
paxalisib specifically inhibits PI3K in the PI3K/AKT kinase (or protein kinase B)
signaling pathway, thereby inhibiting the activation of the PI3K signaling pathway.
This may result in the inhibition of both cell growth and survival in susceptible
tumor cell populations. Activation of the PI3K signaling pathway is frequently associated
with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance
to a variety of antineoplastic agents.;
UNII : P5DKZ70636;
InChIKey : LGWACEZVCMBSKW-UHFFFAOYSA-N;
CAS number : 1382979-44-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1382979-44-3
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G-SRS /a ;
Molecule name : GDC-0084;
NCI Metathesaurus CUI : CL446606;
Origin ID : C116877;
UMLS CUI : C5418157;
Semantic type(s)
- concept_is_in_subset
- has_target
