Preferred Label : STAT Inhibitor OPB-111077;
NCIt definition : An orally bioavailable inhibitor of one or more signal transducer and activator of
transcription (STAT) protein(s), with potential antineoplastic activity. Upon oral
administration, OPB-111077 binds to and inhibits the phosphorylation of STATs. This
prevents binding of STATs to DNA sequences on a variety of STAT-responsive gene promoters,
which may result in the inhibition of both STAT-mediated transcription and tumor cell
proliferation. STATs are constitutively activated in a variety of cancers and play
a key role in tumor cell proliferation.;
Molecule name : OPB-111077;
NCI Metathesaurus CUI : CL446660;
Origin ID : C116873;
UMLS CUI : C3896795;
Semantic type(s)
- concept_is_in_subset
- has_target
