Preferred Label : HDM2 Inhibitor MK-8242;
NCIt definition : An orally bioavailable inhibitor of human homolog of double minute 2 (HDM2), with
potential antineoplastic activity. Upon oral administration, HDM2 inhibitor MK-8242
inhibits the binding of the HDM2 protein to the transcriptional activation domain
of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the
degradation of p53 is inhibited, which may result in the restoration of p53 signaling.
This induces p53-mediated tumor cell apoptosis. HDM2 is a member of the RING finger-type
family of E3 ubiquitin protein ligases and targets p53 for degradation; it is often
overexpressed in cancer cells and has been implicated in cancer cell proliferation
and survival.;
Molecule name : MK-8242; SCH 900242;
NCI Metathesaurus CUI : CL433891;
Origin ID : C116867;
UMLS CUI : C3896809;
Semantic type(s)
- concept_is_in_subset
- has_target
