NCIt definition : An antibody directed against the human alpha5beta1 integrin (a5b1) with potential
antiangiogenic and antineoplastic activities. Anti-a5b1 antibody MINT1526A selectively
binds to a5b1, thereby preventing the binding of integrin ligands. This may result
in the inhibition of endothelial cell-cell interactions, endothelial cell-matrix interactions,
and integrin-mediated tumor angiogenesis and metastasis in a5b1-expressing tumor cells.
a5b1, a cell adhesion and signaling receptor, is often overexpressed on the surface
of tumor vessel endothelial cells and plays a crucial role in both endothelial cell
adhesion and migration.;
Semantic type(s)