" /> Fenebrutinib - CISMeF





Preferred Label : Fenebrutinib;

NCIt synonyms : Bruton Tyrosine Kinase Inhibitor GDC-0853;

NCIt definition : An orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, fenebrutinib inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways, which leads to the inhibition of the growth of malignant B-cells that overexpress BTK. BTK, a member of the Src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B-lymphocyte development, activation, signaling, proliferation and survival.;

UNII : E9L2885WUL;

InChIKey : WNEODWDFDXWOLU-QHCPKHFHSA-N;

CAS number : 1434048-34-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1434048-34-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : GDC-0853;

NCI Metathesaurus CUI : CL774945;

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15/05/2024


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