" /> Fenebrutinib - CISMeF





Preferred Label : Fenebrutinib;

NCIt synonyms : Bruton Tyrosine Kinase Inhibitor GDC-0853;

NCIt definition : An orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, fenebrutinib inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways, which leads to the inhibition of the growth of malignant B-cells that overexpress BTK. BTK, a member of the Src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B-lymphocyte development, activation, signaling, proliferation and survival.;

UNII : E9L2885WUL;

InChIKey : WNEODWDFDXWOLU-QHCPKHFHSA-N;

CAS number : 1434048-34-6;

Molecule name : GDC-0853;

NCI Metathesaurus CUI : CL774945;

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09/05/2025


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