NCIt related terms : FK-330; iNOS Dimerization Inhibitor ASP9853;
NCIt definition : An orally bioavailable small molecule inhibitor of inducible nitric oxide synthase
(iNOS) with potential antineoplastic activity. Upon administration, iNOS Dimerization
Inhibitor FK-330 inhibits iNOS dimerization, which results in decreased nitric oxide
(NO) production. iNOS expression is upregulated in certain cancers and may invoke
a chronic inflammatory state in tumor cells that promotes metastatic growth.;