NCIt definition : An immunoglobulin (Ig) G1 monoclonal antibody directed against both human epidermal
growth factor receptor 3 (HER3 or ERBB3) and human epidermal growth factor receptor
(EGFR), with potential antineoplastic activity. Duligotuzumab binds to both EGFR and
HER3 and inhibits their activation. This may prevent EGFR/HER3-mediated signaling
and inhibit EGFR/HER3-dependent tumor cell proliferation. In addition, MEHD7945A induces
antibody-dependent cell-mediated cytotoxicity (ADCC) against EGR/HER3-expressing tumor
cells. EGFR and HER3, members of the epidermal growth factor receptor (EGFR) family
of receptor tyrosine kinases, are frequently overexpressed in tumors; their expression
is associated with both poor prognosis and drug resistance.;
Semantic type(s)