Preferred Label : Anti-ENPP3/MMAF Antibody-Drug Conjugate AGS-16M8F;
NCIt synonyms : ADC AGS-16M8F; Anti-ENPP3 ADC AGS-16M8F; Anti-ENPP3/MMAF ADC AGS-16M8F;
NCIt definition : An antibody-drug conjugate (ADC) containing a human immunoglobulin (Ig) G2k monoclonal
antibody (AGS-16C) directed against the ectonucleotide pyrophosphatase/phosphodiesterase
family member 3 (ENPP3, NPP3, B10, PDNP3 CD203c, or PD-IBETA ), conjugated, via the
non-cleavable maleimidocaproyl (mc) linker, to monomethyl auristatin F (MMAF), an
auristatin derivative and a potent microtubule inhibitor, with potential antineoplastic
activity. Upon intravenous administration of anti-ENPP3/MMAF ADC AGS-16M8F, the monoclonal
antibody moiety selectively binds to ENPP3 expressed on tumor cells; upon internalization,
the ADC is degraded by lysosomal proteases and MMAF is released. In turn, MMAF binds
to and inhibits tubulin polymerization, which results in G2/M phase arrest and tumor
cell apoptosis. While normally expressed at low levels in the proximal tubules of
the kidney, the type II transmembrane glycoprotein ENPP3 is overexpressed in most
renal neoplasms and some liver cancers.;
Molecule name : AGS-16M8F; AGS 16M8F;
NCI Metathesaurus CUI : CL421575;
Origin ID : C116626;
UMLS CUI : C3896923;
Semantic type(s)
- concept_is_in_subset
- has_target
