Preferred Label : Angiopoietin-2-specific Fusion Protein PF-04856884;
NCIt related terms : CVX-060;
NCIt definition : A humanized monoclonal antibody fused to two peptides that bind to angiopoietin 2
(Ang2; ANGPT2), with potential anti-angiogenic and antineoplastic activities. Upon
intravenous administration, Ang2-targeting PF-04856884 CovX body specifically binds
to Ang2 and prevents the binding of Ang2 to its receptor Tie2 expressed on endothelial
cells. This inhibits Tie2-mediated signaling, prevents angiogenesis and inhibits tumor
cell proliferation. Ang2, a proangiogenic cytokine and ligand for the Tie2 receptor,
plays a key role in the regulation of tumor angiogenesis and tumor cell proliferation;
its expression is upregulated by tumor endothelial cells.;
UNII : 78LXD26OX3;
CAS number : 1415649-10-3;
Molecule name : CVX-060; PF-04856884;
NCI Metathesaurus CUI : CL433732;
Origin ID : C116625;
UMLS CUI : C4049147;
Semantic type(s)
- concept_is_in_subset
- has_target
