Mitomycin A - CISMeF

Preferred Label : Mitomycin A;

NCIt synonyms : Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-6,8a-dimethoxy-5-methyl-, carbamate (ester);

NCIt definition : A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus. Bioreduced mitomycin A generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Mitomycin A is more toxic than mitomycin C due to increased and nonselective DNA cross-linking in both aerobic and hypoxic cells. (NCI04);

UNII : 87TMG6FJHV;

CAS number : 4055-39-4;

NSC code : 75986;

Codes from synonyms : NSC0075986;

Details

Origin ID

C1164;

UMLS CUI

C0066608;

Automatic exact mappings (from CISMeF team)
- Mitomycin [ICHI extension code]
- Mitomycin [SMS substance]
Currated CISMeF NLP mapping
- mitomycin A [MeSH concept]
- mitomycin A [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Product containing mitomycin (medicinal product) [SNOMED CT concept]
- mitomycin [ATC Code]
Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- mitomycin A [MeSH concept]
- mitomycin A [MeSH Supplementary Concept]
Validated automatic mappings to NTBT
- Mitomycin [ICD-11 Extension code]
- Mitomycin (substance) [SNOMED CT concept]
- mitomycin [SNOMED Notion]
- mitomycin [MeSH Descriptor]
- mitomycin [MeSH concept]
- mitomycins [MeSH Descriptor]
- mitomycins [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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