NCIt definition : A polyphenol and the ester of caffeic acid and quinic acid that is found in coffee
and black tea, with potential antioxidant and chemopreventive activities. Chlorogenic
acid scavenges free radicals, which inhibits DNA damage and may protect against the
induction of carcinogenesis. In addition, this agent may upregulate the expression
of genes involved in the activation of the immune system and enhances activation and
proliferation of cytotoxic T-lymphocytes, macrophages, and natural killer cells. Chlorogenic
acid also inhibits the activity of matrix metalloproteinases.;