NCIt definition : An anti-human glucocorticoid-induced tumor necrosis factor receptor (GITR) agonistic
monoclonal antibody (MoAb) with potential immunomodulating activity. Anti-GITR monoclonal
antibody MK-4166 binds to and activates GITRs found on multiple types of T-cells.
This stimulates the immune system and induces both the activation and proliferation
of tumor-antigen-specific T effector cells, and suppresses the function of activated
T regulatory cells. This leads to tumor cell eradication. Also, this agent is shown
to act synergistically with chemotherapeutic drugs in multiple cancer models. GITR,
a member of the TNF receptor superfamily, is expressed on the surface of multiple
types of immune cells, including regulatory T-cells, effector T-cells, B-cells, and
natural killer (NK) cells.;