Hairy/Enhancer-of-Split Related With YRPW Motif-Like Protein

Preferred Label : Hairy/Enhancer-of-Split Related With YRPW Motif-Like Protein;

NCIt synonyms : HRT-3; hHRT3; hHeyL; Hairy-Related Transcription Factor 3; bHLHb33; Class B Basic Helix-Loop-Helix Protein 33; HEY-Like Protein; HEYL;

NCIt definition : Hairy/enhancer-of-split related with YRPW motif-like protein (328 aa, 35 kDa) is encoded by the human HEYL gene. This protein plays a role in both cardiac development and the negative regulation of transcription.;

NCIt note : Hairy/enhancer-of-split related with YRPW motif-like protein binds to the canonical E box sequence 5'-CACGTG-3'. (UniProt);

Details

Origin ID

C114522;

UMLS CUI

C1566530;

Automatic exact mappings (from CISMeF team)
- Hes-related bhlh transcription factor with yrpw motif-like protein [OMIM gene]
OMIM relation
- Hes-related bhlh transcription factor with yrpw motif-like protein [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- HEYL protein, human [MeSH Supplementary Concept]
- HEYL protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- HEYL Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_biochemical_function
- Transcription Repressor/Corepressor [NCIt concept]
gene_product_has_structural_domain_or_motif
- bHLH Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Organogenesis [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- Transcriptional Repression [NCIt concept]

Keyword's position in hierarchy(ies) :

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