NCIt definition : An antibody drug conjugate (ADC) containing a human monoclonal antibody AGS-22 targeting
the cell adhesion molecule nectin-4 and conjugated to the cytotoxic agent monomethyl
auristatin E (MMAE), via a proprietary enzyme-cleavable linker (AGS-22CE), with potential
antineoplastic activity. The monoclonal antibody moiety of enfortumab vedotin selectively
binds to nectin-4. After internalization and proteolytic cleavage, MMAE binds to tubulin
and inhibits its polymerization, which results in G2/M phase arrest and induces apoptosis
in nectin-4 overexpressing tumor cells. Nectin-4, a tumor associated antigen belonging
to the nectin family, is overexpressed in a variety of cancers, including breast,
bladder, lung and pancreatic cancer.;
UNII : DLE8519RWM;
CAS number : 1346452-25-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1346452-25-2
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