Enfortumab Vedotin

Preferred Label : Enfortumab Vedotin;

NCIt synonyms : Anti-Nectin 4 ADC ASG-22CE; Enfortumab Vedotin-ejfv; Anti-nectin-4 Monoclonal Antibody-Drug Conjugate AGS-22M6E;

NCIt definition : An antibody drug conjugate (ADC) containing a human monoclonal antibody AGS-22 targeting the cell adhesion molecule nectin-4 and conjugated to the cytotoxic agent monomethyl auristatin E (MMAE), via a proprietary enzyme-cleavable linker (AGS-22CE), with potential antineoplastic activity. The monoclonal antibody moiety of enfortumab vedotin selectively binds to nectin-4. After internalization and proteolytic cleavage, MMAE binds to tubulin and inhibits its polymerization, which results in G2/M phase arrest and induces apoptosis in nectin-4 overexpressing tumor cells. Nectin-4, a tumor associated antigen belonging to the nectin family, is overexpressed in a variety of cancers, including breast, bladder, lung and pancreatic cancer.;

UNII : DLE8519RWM;

CAS number : 1346452-25-2;

Drug name : Padcev;

Molecule name : ASG-22CE; AGS 22ME; AGS-22M6E; ASG 22CE;

NCI Metathesaurus CUI : CL472325;

Codes from synonyms : 3563;

Details

Origin ID

C114500;

UMLS CUI

C4519740;

Currated CISMeF NLP mapping
- Enfortumab vedotin [SMS substance]
- Enfortumab vedotin (substance) [SNOMED CT concept]
- enfortumab vedotin [MeSH concept]
- enfortumab vedotin [MeSH Supplementary Concept]
Manual BTNT mappings - CISMeF
- enfortumab vedotin [ATC Code]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Enfortumab vedotin (substance) [SNOMED CT concept]
- Product containing enfortumab vedotin (medicinal product) [SNOMED CT concept]
- enfortumab vedotin [MeSH Supplementary Concept]
- enfortumab vedotin [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Enfortumab Vedotin Regimen [NCIt concept]
- Enfortumab Vedotin/Pembrolizumab Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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