Belantamab Mafodotin

Preferred Label : Belantamab Mafodotin;

NCIt synonyms : J6M0-mcMMAF; Belantamab Mafodotin-blmf;

NCIt definition : An antibody-drug conjugate (ADC) consisting of belantamab, an afucosylated, humanized monoclonal antibody, directed against the B-cell maturation antigen (BCMA), conjugated to mafodotin, an auristatin analogue and microtubule inhibitor monomethyl auristatin phenylalanine (MMAF), with potential antineoplastic activity. Upon administration of belantamab mafodotin, the anti-BCMA antibody moiety selectively binds to BCMA on tumor cell surfaces. Upon internalization, the MMAF moiety binds to tubulin and inhibits its polymerization, which results in G2/M phase arrest and induces tumor cell apoptosis. In addition, belantamab mafodotin induces antibody-dependent cellular cytotoxicity (ADCC). Altogether, this results in the inhibition of cellular proliferation in tumor cells that overexpress BCMA. BCMA, a receptor for a proliferation-inducing ligand and B-cell activating factor, is a member of the tumor necrosis factor (TNF) receptor superfamily and plays a key role in plasma cell survival; it is found on the surfaces of plasma cells and overexpressed on malignant plasma cells. Afucosylation of the antibody moiety increases ADCC.;

UNII : DB1041CXDG;

CAS number : 2050232-20-5;

Drug name : Blenrep;

Molecule name : GSK-2857916; GSK 2857916;

NCI Metathesaurus CUI : CL471808;

Codes from synonyms : 4380;

Details

Origin ID

C114299;

UMLS CUI

C5227411;

Currated CISMeF NLP mapping
- Belantamab mafodotin [SMS substance]
- Belantamab mafodotin (substance) [SNOMED CT concept]
- belantamab mafodotin [MeSH Supplementary Concept]
- belantamab mafodotin [MeSH concept]
Manual BTNT mappings - CISMeF
- belantamab mafodotin [ATC Code]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Belantamab mafodotin (substance) [SNOMED CT concept]
- Product containing belantamab mafodotin (medicinal product) [SNOMED CT concept]
- belantamab mafodotin [MeSH Supplementary Concept]
- belantamab mafodotin [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Tumor Necrosis Factor Receptor Superfamily Member 17 [NCIt concept]
is_component_of_chemotherapy_regimen
- Belantamab Mafodotin Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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