Preferred Label : ALK/TRK Inhibitor TSR-011;
NCIt definition : An orally available inhibitor of both the receptor tyrosine kinase anaplastic lymphoma
kinase (ALK) and the tropomyosin-related kinases (TRK) TRKA, TRKB, and TRKC, with
potential antineoplastic activity. Upon administration, ALK/TRK inhibitor TSR-011
binds to and inhibits both ALK and TRK kinases. The inhibition leads to disruption
of ALK- and TRK-mediated signaling and impedes tumor cell growth in ALK/TRK-overexpressing
tumor cells. ALK belongs to the insulin receptor superfamily and plays an important
role in nervous system development; ALK dysregulation and gene rearrangements are
associated with a series of tumors. TRK, a family of receptor tyrosine kinases activated
by neurotrophins, is mutated in a variety of cancer cell types and plays an important
role in tumor cell growth and survival.;
Molecule name : TSR-011;
NCI Metathesaurus CUI : CL471796;
Origin ID : C114287;
UMLS CUI : C3827071;
Semantic type(s)
- concept_is_in_subset
- has_target
