Preferred Label : Melanoma-Associated Antigen Family;
NCIt synonyms : MAGE Family; Melanoma-Associated Antigen; MAGE;
NCIt definition : A family of proteins that were first detected in male germ cells, placenta and various
tumors that were originally not found in normal tissues. Their genes are located in
four clusters on the X chromosome. All of the members of the family share a stretch
of about 200 amino acids, called the MAGE conserved domain, which is usually located
near the C-terminal end of the protein and may allow MAGE proteins to interact with
cellular receptors. For most members their entire coding sequences are located in
the last exon of their respective genes.;
NCIt note : There are 4 subfamilies in the MAGE family. MAGE-A through -D. The MAGE-D subgroup
members are well conserved between murine and human species and their genomic structure
indicates that one of them may be the founder for the entire MAGE family. (Cancer
Res. 2001; 61:5544-51.);
PubMed : 11454705;
Origin ID : C113841;
UMLS CUI : C3812726;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
