NCIt definition : An orally available, irreversible, inhibitor of lysine specific demethylase 1 (LSD1),
with potential antineoplastic activity. Upon administration, GSK2879552 binds to and
inhibits LSD1, a demethylase that suppresses the expression of target genes by converting
the dimethylated form of lysine at position 4 of histone H3 (H3K4) to mono- and unmethylated
H3K4. LSD1 inhibition enhances H3K4 methylation and increases the expression of tumor-suppressor
genes. This may lead to an inhibition of cell growth in LSD1-overexpressing tumor
cells. LSD1, overexpressed in certain tumor cells, plays a key role in tumor cell
growth and survival.;
Semantic type(s)