Preferred Label : AICA-Ribotide;
NCIt synonyms : 1H-Imidazole-4-Carboxamide, 5-Amino-1-(5-O-Phosphono-Beta-D-Ribofuranosyl)- (9CI); Imidazole-4-Carboxamide, 5-Amino-1-Beta-D-Ribofuranosyl-, 5'-(Dihydrogen Phosphate)
(8CI); 5-Amino-1-(5-Phospho-D-Ribosyl)Imidazole-4-Carboxamide; AICA Ribotide; 5-Phosphoribosyl-4-Carbamoyl-5-Aminoimidazole; Aminoimidazole Carboxamide Ribonucleotide; ZMP; 5-Amino-1-(5-O-Phosphono-Beta-D-Ribofuranosyl)-1H-Imidazole-4-Carboxamide; AICAR; AICA Ribonucleotide; 1-(5'-Phosphoribosyl)-5-Amino-4-Imidazolecarboxamide; 5-Amino-4-Imidazole Carboxamide Ribonucleotide; 5'-Phospho-Ribosyl-5-Amino-4-Imidazole Carboxamide; 5'-Phosphoribosyl-5-Amino-4-Imidazolecarboxamide; 5-Amino-4-Imidazolecarboxamide Ribonucleoside 5'-Monophosphate; 5-Amino-4-Imidazolecarboxamide Ribotide; [(2R,3S,4R,5R)-5-(4-Carbamoyl-5-Aminoimidazol-1-yl)-3,4-Dihydroxyoxolan-2-yl]Methyl
Dihydrogen Phosphate; 5-Aminoimidazole-4-Carboxamide Ribonucleotide;
NCIt definition : A ribonucleotide analog of adenosine monophosphate that is an intermediate in the
synthesis of inosine monophosphate with potential cardioprotective activity. During
myocardial ischemia, AICA-ribotide activates AMP-dependent protein kinase (AMPK),
inhibits adenosine deaminase (ADA) and causes increased synthesis of both adenosine
and adenosine triphosphate (ATP). These activities prevent calcium overload, increase
AMPK-dependent glucose uptake and improve blood flow to the heart. AMPK, a protein
kinase complex, regulates several cellular systems including the uptake of glucose,
the beta-oxidation of fatty acids, protein synthesis, and the biogenesis of both glucose
transporter 4 (GLUT4) and mitochondria. ADA is a key enzyme involved in purine metabolism.;
CAS number : 3031-94-5;
ChEBI ID : CHEBI:18406;
Origin ID : C113498;
UMLS CUI : C0051028;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
